The research protocol was reviewed and approved by the Independent Ethics Committee, EKOS (Ethikkommission Ostschweiz) on 16.12.2016 (BASEC Nr. All of the studies involved measurements of objective and subjective parameters of efficacy (spirometric and auscultation parameters such as vital capacity, forced vital capacity, and forced expiratory volume per 1 second). Comparable improvement was seen for all symptoms between both groups from the entry to final visit which was statistically significant. Material and Methods. This medicine is available without prescription. Alternative & Herbal Products. Hedera helix. The validated method was successfully applied to quantify all six compounds in a 30% ethanol ivy leaf extract and 13 ivy leaf extract products. Two-hundred and sixty-eight children aged 0-12 yr were … - Keep this leaflet. The data used to support the findings of this study are available from the corresponding author upon request. Hedera helix preparations (ivy leaf extracts) are worldwide marketed for the treatment of different diseases of the respiratory tract system and include catarrh of the respiratory passages; symptomatic treatment of chronic inflammatory bronchial illnesses; and acute inflammations of the respiratory tract accompanied by coughing (HMPC Assessment) . Active ingredient: Each 5 ml of syrup contains 35 mg of extract (as dry extract) from ivy leaf (Hedera helix L.) (5 - 7.5 : 1). Ivy leaves (hederae helicis folium) exert an expectorant and antispasmodic action on the respiratory tract . 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In fact, a 2012 study involving 268 children, 0 to 12 years old, discovered that 14 days of treatment with ivy leaf extract (in the form of a cough syrup) was a safe and effective treatment for children with a cough. Material and Methods. Ivy Syrup IVY LEAF EXTRACT 50 mg Read all of this leaflet carefully because it contains important information for you. Hecker M. Efficacy and tolerance of Ivy extract (Prospan®) in patients suffering from respiratory tract diseases. Herbion Naturals Ivy Leaf Syrup with Thyme and Licorice, 5 fl oz- Helps Maintain Respiratory and Bro… The present noninterventional study was intended to gain further data on the application of a cough syrup containing ivy leaf extract EA 575® by evaluating its efficacy and safety in children and adults with symptoms of acute bronchitis. These positive results for the herbal medication correspond to the pharmacological actions of ivy. At the inclusion visit, demographic and anamnestic data as well as the indication and typical complaints were recorded in the case report form. Symptoms could last up to 3 days and not longer to assure the acute situation. Introduction: Ivy leaf extract is an essential oil extracted from plant leaves. Significant improvement in each of the symptoms from the entry visit to final visit (, Average values of physician`s evaluation for severity of disease and calculated BSS score at entry and final visit in both groups comparing the final visit with the entry visit. The exclusive ivy extract in Bronchial Soothe provides herbal support for optimal lung and bronchial passageway health. Non-drowsy, sugar-free, alcohol-free, no added coloring with pleasant natural blackcurrant flavor. There were 4 different consent forms used in the study depending on the age of the subjects: one consent form for adult subjects, one form for subjects ranging between 14 and 18 years old (signed by the subjects), one form for subjects between ages 11 and 13 years who can already read the document by themselves (signed by the parents), and one form for parents of subjects between 6 and 11 years (signed by parents). * Give Twice Daily Not to exceed 2 servings in 24 hours Esther Kruttschnitt, Tankred Wegener, Catherine Zahner, Silke Henzen-Bücking, "Assessment of the Efficacy and Safety of Ivy Leaf (Hedera helix) Cough Syrup Compared with Acetylcysteine in Adults and Children with Acute Bronchitis", Evidence-Based Complementary and Alternative Medicine, vol. 24.6% of the subjects from the EA 575® group suffered from acute bronchitis caused by bacterial infection and 19.0% in the ACC group (Table 2). In summary, the study showed that both preparations are effective and safe in the treatment of bronchitis. This limitation can be addressed in further interventional studies with an randomized study design. Sign up here as a reviewer to help fast-track new submissions. These components are supportive of healthy mucous membranes and defend against occasional irritation of the lung and bronchial passages. 2016-01555). from a wet cough; active substance: ivy leaf extract; syrup; country of production: Ukraine Liver disorders. Description. The tolerability of the herbal medication was very good. This advantage could be demonstrated by the improvement of coughing fits, sputum, rales, dyspnoea, and severity of the disease during the 7 day-treatment as the primary outcome which was expressed by the BSS. Formulations similar to Coferb have been recognized by international clinical trials endorsing safety and efficacy of the product. Another noninterventional study investigated the efficacy and safety of EA 575® in school children with acute bronchitis showing the same improvement in the BSS . PROSPANEX® Cough Syrup: 5 ml contains 35 mg Hedera helix leaves dry extract (DER 5–7.5 : 1) as active ingredient, manufactured by Engelhard Arzneimittel GmbH and Co. KG. Furthermore, concomitant diseases were treated with different antibiotics or other treatment which also might have an impact on the treatment outcome for the acute bronchitis. The criteria for inclusion of the patient’s data in the study documentation were as follows: signing the informed consent, age six years and older, and having symptoms of an acute bronchitis accompanied with productive cough for at least 3 days for whom a therapy with EA 575® or ACC is indicated according to the physician. $16.39$16.39 ($3.21/Fl Oz) FREE Shipping. Maty's Organic Mucus Cough Syrup, Made with Organic Honey, Thyme & Ginger - 6 fl oz. 7 children were noted in the class group 11–13 years with an average height of 137.1 cm and an average weight of 37.0 kg. In addition, approximately 50% of patients with acute bronchitis report the production of purulent sputum . The severity of the disease started with 4.3 points in the EA 575® group and with 4.24 points in the ACC group showing a moderate status of disease. Recommended dosage according to the Swiss patient leaflet: for children six years and older, 5 ml, three times daily, and for adults, 7.5 ml, three times daily. Observations of the tolerability were comparable for both products. Sydler Remedies Private Limited - Category: Pharma & Supplements. These effects are attributable, in particular, to the therapeutically important constituents of the ivy leaf extract, which belong to the class of triterpene saponins such as hederacoside C (Figure 1), a marker and an active ingredient of ivy leaf extract [7–10]. In the ACC group, 21 × 7.48 = 157 patient days were calculated together across all dosage forms. described the mode of action stating that α-hederin inhibited the terbutaline-stimulated internalization of the β2-AR. Ivy leaf Extract Syrup. Each patient had the right to terminate the study participation at any time. Criteria for exclusion of the documentation were as follows: known hypersensitivity to the active ingredients, treatment with the medications in the last two weeks before study entry, participation in another trial in the same time, and legal incapacity. More info about ivy leaf extract. Ivy leaf dry extract HRS European Pharmacopoeia (EP) Reference Standard; find null-Y0001592 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Ivy leaf is a source of saponins, sterols, flavonoids. It is the most common disease in industrialized countries, and thus herbal expectorants enjoy a high popularity in many European countries due to their favorable risk-benefit ratio. Both, physicians and patients described the efficacy of EA 575® comparable with acetylcysteine. Acute cough is mainly caused by viral infection [5–8]. Before recruitment, the study procedure was explained to the subjects in detail, after which they signed consent forms. Furthermore bronchial muscle cells reduce under β2-stimulating conditions the intracellular Ca2+ level. Compared with the conventional quality control method that measures the contents of hederacoside C in ivy leaf extracts, the newly developed method can provide more information about the chemical composition of ivy leaf extracts. Relevant concomitant diseases and treatments. If the standard deviations of the difference were on average not higher than 2 score points and the alpha error = 0.05, then  the nonparametric Mann–Whitney would demonstrate a statistical power (beta error) of more than 90% (GPower, Version 3.1.9, University of Düsseldorf, Germany). Further symptoms are fever and sore throat . Extraction solvent: ethanol 30 % w/w. Cough after acute bronchitis typically persists for 10 to 20 days. containing ivy leaf extract. Acute bronchitis is usually a self-limited condition. Diseases with the leading symptom “cough” are economically relevant as respiratory diseases are the most common reason for working incapacity and affect the quality of patient’s life . Review articles are excluded from this waiver policy. Probably the drug-related AEs (adverse drug reactions (ADRs)) were in accordance with the known side-effect profile of ivy preparations. At the final visit after seven days of treatment, there was a comparable improvement in both groups for all assessments except dyspnoea and number of cough attacks which showed a higher improvement in the EA 575® group compared with ACC. Coughing fits was the most common finding. * Then, we add Turmeric Root for nasal support and Vitamin C and Zinc for immune support. Botanical names: Hedera helix How It Works Although ivy's composition has not been subject to detailed scientific investigations, it is known to contain 5–8% saponins. Results of this multicenter study proved the advantage of the treatment of ivy leaves in acute bronchitis that is evidently comparable with acetylcysteine. Drop-outs were only those patients, for which no data after intake of the medication were available. Sieben et al. Subsequently, treatments were prescribed by the doctor. Subgroup evaluation was performed within the EA 575® group regarding indication at inclusion into the study and concomitant disease or infection. ivy leaf extract cough offered on the site come in multiple forms such as capsules, powders, and tablets to suit the needs of children and adults alike. For dyspnoea during coughing, better improvement was seen in the EA 575® group. I was prescribed ivy leaf extract for my (quite heavy) cough. The study revealed a significant and clinically relevant improvement in patients with acute bronchitis receiving oral treatment with EA 575®. Significant improvement in each of the symptoms from entry visit to final visit (, Assessment of the Efficacy and Safety of Ivy Leaf (, Max Zeller Söhne AG, Seeblickstrasse 4, Romanshorn 8590, Switzerland, CONSULTING HMP, Brückstrasse 11, Weinheim 69469, Germany, Landarztpraxis Sevelen, Velturrietstrasse 5, Sevelen 9475, Switzerland, Evidence-Based Complementary and Alternative Medicine, Acute bronchitis, caused by bacterial infection (ICD-10: J20.0-J20.2) [, Acute bronchitis, caused by viral infection (ICD-10: J20.3-J20.7), Other acute inflammation of the respiratory tract accompanied with cough, The average duration of symptoms at entry visit (days), Concomitant infections and other diseases, None (N; % of patient within treatment group), R. P. Wenzel and A. Average values of physician’s evaluation comparing the final visit with the entry visit. Maty's Organic Children's Mucus Cough Syrup, Made with Organic Honey, Thyme & Ginger - 6 fl oz. The current noninterventional study was performed in 118 patients using EA 575® and 21 patients using ACC for the treatment of acute bronchitis. Two galenical formulations of an ivy herbal extract, syrup and cough drops, were tested for their efficacy and safety in the paediatric treatment of cough and bronchitis in two independent open, non-interventional studies with identical design. After viewing product detail pages, look here to find an easy way to navigate back to pages you are interested in. Husten und Auswurf: ursachen und Differentialdiagnosen,”, J. E. DeLozier and R. O. Gagnon, “National ambulatory medical care survey: 1989 summary,”, K. F. Chung and I. D. Pavord, “Prevalence, pathogenesis, and causes of chronic cough,”, C. C. S. Lang and T. Wegener, “Efeu in der pädiatrischen Praxis,”, A. Schaefer, F. Ludwig, B. M. Giannetti, M. Bulitta, and A. Wacker, “Efficacy of two dosing schemes of a liquid containing ivy leaves dry extract EA 575 versus placebo in the treatment of acute bronchitis in adults,”, A. Schaefer, M. S. Kehr, B. M. Giannetti, M. Bulitta, and C. Staiger, “A randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of a liquid containing ivy leaves dry extract (EA 575((R))) vs. placebo in the treatment of adults with acute cough,”, P. Kardos, Q. Dinh, K.-H. Fuchs et al., “Leitlinie der deutschen gesellschaft für pneumologie und beatmungsmedizin zur diagnostik und therapie von erwachsenen patienten mit husten,”, P. Kardos, S. Lehrl, W. Kamin, and H. Matthys, “Assessment of the effect of pharmacotherapy in common cold/acute bronchitis - the bronchitis severity scale (BSS),”, B. Kemmerich, R. Eberhardt, and H. Stammer, “Efficacy and tolerability of a fluid extract combination of thyme herb and ivy leaves and matched placebo in adults suffering from acute bronchitis with productive cough,”, F. J. Martinez, “Acute bronchitis: state of the art diagnosis and therapy,”, A. Gillissen, C. Gessner, S. Hammerschmidt, G. Hoheisel, and H. Wirtz, “Acute bronchitis: when are antibiotics, and when is symptomatic treatment indicated?”, G. Höffken, J. Lorenz, W. Kern et al., “S3-guideline on ambulant acquired pneumonia and deep airway infections,”, N. A. Sathe, S. Krishnaswami, J. Andrews, C. Ficzere, and M. L. McPheeters, “Pharmacologic agents that promote airway clearance in hospitalized subjects: a systematic review,”, Y. Bolbot, E. Prokhorov, S. Mokia, and A. Yurtseva, “Comparing the efficacy and safety of high-concentrate (5-7.5:1) ivy leaves extract and acetylcysteine for treatment of children with acute bronchitis,”, A. Sieben, L. Prenner, T. Sorkalla et al., “Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors,”. Two galenical formulations of an ivy herbal extract, syrup and cough drops, were tested for their efficacy and safety in the paediatric treatment of cough and bronchitis in two independent open, non‐interventional studies with identical design. The stimulation of β2-AR provides an increased surfactant production which leads to the liquefaction of the mucus. English ivy exhibits antiviral, antimycotic, and anthelmintic and effects and some studies indicate that the Ivy Leaf Cough Syrup Benefits: Natural formula to reduce coughing, soothe airways and to clear mucus and phlegm or effective congestion and cough relief. The same extract is contained as active ingredient in the present noninterventional study. The study was conducted at 25 medical practices throughout Switzerland as prospective, open, noninterventional study. The average age was 44.3 years for the EA 575® group and 49.1 years for the ACC group. There was a significant improvement in the reduction of both groups from baseline to end visit. * Within the 139 included patients, only 21 patients were prescribed an acetylcysteine preparation resulting in an unequal group distribution. ACC mono acetylcysteine preparation (granulate, syrup, or effervescent tablet, products available in the Swiss market): The following doses are recommended according to the summary of product characteristics. Data from a large clinical trial revealed that the median duration of cough from acute bronchitis due to all causes was 18 days . The authors declare that there are no conflicts of interest. Over the entire treatment period, there was a reduction to 1.8 points in the EA 575® group and to 2.1 points in the ACC groups corresponding to a low impairment in both groups and showing a comparable continuous improvement in both groups. Zarbee's Naturals Cough & Throat Relief + Mucus Nighttime Drink Mix, Apple Spice Flavor, 6 Packets, FREE Shipping on orders over $25 shipped by Amazon, Zarbee's Naturals 99% Honey Cough Soothers, Natural Lemon Flavor, 14 Count, Zarbee's Naturals Baby Cough Syrup* + Mucus, Natural Grape Flavor, 2 Ounces, Integrative Therapeutics - Sambucus - Black Elderberry Syrup - Support Immune System & Cold and Flu Relief Supplement - Berry Flavor - 4 fl oz, Nature's Way Bronchial Soothe Ivy Leaf 99.9% Alcohol-free Non-Drowsy Syrup, 120 ML (4 Fl Oz. And Vitamin C and Zinc for immune ivy leaf extract syrup the ninth most common among! Age was 44.3 years for the ACC group $ 3.21/Fl oz ) FREE Shipping is defined as bronchodilator. 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